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In an ATP-dependent manner, ACSL4 catalyzes the binding of AA or AdA to coenzyme A to form derived AA-CoA or AdA-CoA ( Figure 3 2.2.2 Lipid metabolism in glioma Increased fatty acid synthesis and increased cholesterol uptake are considered to be features of malignant glioma

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58 Phase 2a trial of GSBR-1290 (120mg) in 40 healthy obese volunteers over 8 weeks demonstrated a significant reduction in BW (120 mg: -4.74%